AFG1L

Across TCGA patient cohorts, AFG1L mutation is significantly associated with the RNA expression of many other genes, with 1,127 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFG1L-associated genes across cancer lineages are OR2B3, RNU6-679P, and EXOGP1. Each is linked with AFG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both AFG1L-to-partner and partner-to-AFG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B3 grouped by AFG1L-low versus AFG1L-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG1L→partner) and Y-score (partner→AFG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR2B3 →	+0.055	+5.087	.003	.004	3	2
LUAD	RNU6-679P →	+0.584	+4.481	.001	.009	3	2
LUAD	EXOGP1 →	+0.048	+5.315	<.001	.003	3	2
LUAD	MIR4478 →	+0.425	+5.912	<.001	.001	3	2
LUSC	RNU6-1246P →	+0.489	+4.736	<.001	.001	3	2
LUSC	RNA5SP521 →	+0.699	+4.370	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,127 associations by consensus.

OR2B3 by AFG1L expression — LUAD

Explore this box plot interactively →