AFG1L

Across TCGA patient cohorts, AFG1L mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFG1L-associated genes across cancer lineages are INPP4B, JNK2, and MSH2. Each is linked with AFG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both AFG1L-to-partner and partner-to-AFG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by AFG1L-low versus AFG1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG1L→partner) and Y-score (partner→AFG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.396	-3.169	.011	.018	3	1
UCEC	JNK2 →	+0.279	+3.179	.003	.010	3	1
UCEC	MSH2 →	-0.310	-3.160	.005	.019	3	1
UCEC	p70-S6K_pT389 →	-0.245	-2.312	.007	.034	3	1
UCEC	Rab25 →	-0.345	-3.584	.031	.002	3	1
UCEC	Annexin-1 →	+0.851	+3.019	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

INPP4B by AFG1L expression — UCEC

Explore this box plot interactively →