AFG1L

Across TCGA cell cohorts, AFG1L mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFG1L-associated genes across cancer lineages are DPRX, LCE1C, and IFNA14. Each is linked with AFG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both AFG1L-to-partner and partner-to-AFG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by AFG1L-low versus AFG1L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG1L→partner) and Y-score (partner→AFG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DPRX →	+0.068	+5.321	<.001	.005	3	1
OVARY	LCE1C →	+0.058	+5.196	<.001	.005	3	1
OVARY	IFNA14 →	+0.022	+5.196	<.001	.005	3	1
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
LARGE_INTESTINE	DDX4 →	+0.029	+4.032	.007	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DPRX by AFG1L expression — CNS

Explore this box plot interactively →