AFG1L

Across TCGA cell cohorts, AFG1L mutation is significantly associated with the mutation status of many other genes, with 3,457 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFG1L-associated genes across cancer lineages are CACNA1I, SUPT6H, and DOCK7. Each is linked with AFG1L in more than 3 cancer types. Because this analysis shows association rather than direction, both AFG1L-to-partner and partner-to-AFG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1I grouped by AFG1L-low versus AFG1L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG1L→partner) and Y-score (partner→AFG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CACNA1I →	+4.044	+5.000	.008	.008	1	4
CNS	SUPT6H →	+4.044	+5.000	.008	.008	1	4
CNS	DOCK7 →	+4.459	+5.277	.005	.005	1	4
LARGE_INTESTINE	HCN1 →	+2.321	+2.919	.003	.003	1	4
LARGE_INTESTINE	PCNX3 →	+2.000	+3.169	.002	.002	1	4
LARGE_INTESTINE	OSBPL5 →	+4.000	+3.459	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,457 associations by consensus.

CACNA1I by AFG1L expression — CNS

Explore this box plot interactively →