AFF4

Across TCGA pan-cancer cohorts, AFF4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AFF4 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AFF4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AFF4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where AFF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.426	0.735	.009	9	view →
HNSC	DFS	Median	IV	1.000	0.927	.048	2	view →
CCRCC	OS	Median	II,III,IV	1.000	0.449	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AFF4–LUAD (DFS)

Open the LUAD breakdown →