AFF4

Across TCGA patient cohorts, AFF4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,582 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AFF4-associated proteins across cancer lineages are TP53BP1_S598, PLCG2, and IRF4. Each is linked with AFF4 in more than 4 cancer types. Because this analysis shows association rather than direction, both AFF4-to-partner and partner-to-AFF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFF4 versus TP53BP1_S598 in GBM, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF4→partner) and Y-score (partner→AFF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TP53BP1_S598 →	+0.863	+0.343	<.001	<.001	3	4
LSCC	PLCG2 →	-0.484	-0.343	<.001	<.001	3	4
UCEC	IRF4 →	-0.803	-0.442	.005	.005	2	5
GBM	KDM3B →	+0.280	+0.303	<.001	<.001	3	4
LSCC	SPCS3 →	-0.561	-0.287	<.001	.006	3	4
BRCA	MZB1 →	-0.862	-0.598	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,582 associations by consensus.

AFF4 vs TP53BP1_S598 — GBM

Explore this scatter interactively →