AFF4

Across TCGA patient cohorts, AFF4 mutation is significantly associated with the RNA expression of many other genes, with 4,887 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF4-associated genes across cancer lineages are GBP5, C12orf43, and NEXN. Each is linked with AFF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFF4-to-partner and partner-to-AFF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBP5 grouped by AFF4-low versus AFF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF4→partner) and Y-score (partner→AFF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GBP5 →	+0.998	+2.247	<.001	<.001	3	3
UCEC	C12orf43 →	+0.276	+2.010	<.001	<.001	3	3
UCEC	NEXN →	+0.416	+1.805	.006	<.001	3	3
UCEC	RRM1 →	+0.870	+2.807	<.001	<.001	3	3
UCEC	RNF34 →	+0.275	+2.178	.002	<.001	3	3
UCEC	PGAM1 →	+0.737	+2.053	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,887 associations by consensus.

GBP5 by AFF4 expression — UCEC

Explore this box plot interactively →