AFF4

Across TCGA patient cohorts, AFF4 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF4-associated genes across cancer lineages are mTOR_pS2448, MEK1, and Chk1. Each is linked with AFF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFF4-to-partner and partner-to-AFF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by AFF4-low versus AFF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF4→partner) and Y-score (partner→AFF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.124	-2.401	.007	.002	3	3
UCEC	MEK1 →	+0.339	+1.893	.002	<.001	3	2
SKCM	Chk1 →	+0.332	+2.824	<.001	.034	3	2
COAD	PDCD4 →	-0.545	-3.450	.004	.005	3	2
COAD	TSC1 →	-0.431	-2.321	<.001	.033	3	2
COAD	beta-Catenin →	-1.053	-3.000	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

mTOR_pS2448 by AFF4 expression — UCEC

Explore this box plot interactively →