AFF4

Across TCGA cell cohorts, AFF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,981 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AFF4-associated GO terms across cancer lineages are Post-Golgi vesicle-mediated transport, Positive regulation of organelle assembly, and Regulation of organelle assembly. Each is linked with AFF4 in more than 17 cancer types. Because this analysis shows association rather than direction, both AFF4-to-partner and partner-to-AFF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-Golgi vesicle-mediated transport grouped by AFF4-low versus AFF4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF4→partner) and Y-score (partner→AFF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Post-Golgi vesicle-mediated transport →	+0.070	+0.743	.001	<.001	3	18
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.069	+0.779	<.001	<.001	3	18
STOMACH	Regulation of organelle assembly →	+0.053	+1.078	.001	<.001	3	18
STOMACH	Regulation of macroautophagy →	+0.095	+1.307	<.001	.001	3	17
BONE	Regulation of hippo signaling →	+0.102	+0.766	<.001	<.001	3	17
STOMACH	Golgi vesicle transport →	+0.083	+1.070	<.001	.006	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,981 associations by consensus.

Post-Golgi vesicle-mediated transport by AFF4 expression — BONE

Explore this box plot interactively →