AFF4

Across TCGA cell cohorts, AFF4 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFF4-associated genes across cancer lineages are UCMA, NEUROG1, and KRTAP4-1. Each is linked with AFF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFF4-to-partner and partner-to-AFF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCMA grouped by AFF4-low versus AFF4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF4→partner) and Y-score (partner→AFF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UCMA →	+0.207	+4.754	<.001	.005	3	2
CNS	NEUROG1 →	+1.920	+4.169	<.001	.008	3	2
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
LUNG_SCLC	OR10G7 →	+0.022	+5.029	<.001	.006	3	1
LUNG_SCLC	SLC22A6 →	+0.099	+5.029	<.001	.006	3	1
LUNG_SCLC	HNRNPCL3 →	+0.049	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

UCMA by AFF4 expression — CNS

Explore this box plot interactively →