AFF3

Across TCGA patient cohorts, AFF3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,002 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AFF3-associated genes across cancer lineages are MRGBP, SNX8, and GALNT18. Each is linked with AFF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFF3-to-partner and partner-to-AFF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFF3 versus MRGBP in UCEC, with a Pearson correlation of -0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF3→partner) and Y-score (partner→AFF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRGBP →	-1.142	-0.961	.005	.005	3	2
UCEC	SNX8 →	-0.977	-1.021	.001	.001	3	2
UCEC	GALNT18 →	-1.738	-0.902	<.001	.002	3	2
UCEC	BFSP1 →	-1.247	-1.032	<.001	.003	3	2
BRCA	SMO →	-1.291	-0.932	<.001	<.001	3	2
UCEC	HAUS8 →	-0.816	-1.014	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,002 associations by consensus.

AFF3 vs MRGBP — UCEC

Explore this scatter interactively →