AFF3

Across TCGA patient cohorts, AFF3 mutation is significantly associated with the RNA expression of many other genes, with 6,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF3-associated genes across cancer lineages are PCCB, NARS1, and CHAF1A. Each is linked with AFF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both AFF3-to-partner and partner-to-AFF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCCB grouped by AFF3-low versus AFF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF3→partner) and Y-score (partner→AFF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCCB →	+0.339	+1.771	.004	<.001	3	5
CESC	NARS1 →	+0.420	+2.145	.004	.009	3	5
UCEC	CHAF1A →	+0.734	+2.828	<.001	<.001	3	5
UCEC	PBK →	+0.863	+2.126	<.001	<.001	3	5
UCEC	ZWILCH →	+0.548	+1.595	<.001	<.001	3	5
UCEC	MCM10 →	+0.693	+1.750	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,037 associations by consensus.

PCCB by AFF3 expression — UCEC

Explore this box plot interactively →