AFF3

Across TCGA patient cohorts, AFF3 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF3-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with AFF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both AFF3-to-partner and partner-to-AFF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by AFF3-low versus AFF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF3→partner) and Y-score (partner→AFF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.410	+1.999	.007	.008	3	4
COAD	Caspase-7-cleavedD198 →	+0.846	+2.008	<.001	.001	3	4
UCEC	4E-BP1 →	+0.441	+2.237	<.001	<.001	2	5
LUAD	FASN →	+0.494	+3.169	.034	.019	3	3
LUSC	cIAP →	+0.121	+2.709	.015	.003	3	3
COAD	IGFBP2 →	+0.498	+1.874	.025	.047	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

GAPDH by AFF3 expression — UCEC

Explore this box plot interactively →