AFF3

Across TCGA cell cohorts, AFF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,302 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AFF3-associated GO terms across cancer lineages are Positive regulation of establishment of T cell polarity, Regulation of heart rate by cardiac conduction, and Actin filament depolymerization. Each is linked with AFF3 in more than 9 cancer types. Because this analysis shows association rather than direction, both AFF3-to-partner and partner-to-AFF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of establishment of T cell polarity grouped by AFF3-low versus AFF3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF3→partner) and Y-score (partner→AFF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of establishment of T cell polarity →	+0.206	+2.050	<.001	<.001	3	10
URINARY_TRACT	Regulation of heart rate by cardiac conduction →	-0.210	-1.505	<.001	.005	3	9
BONE	Actin filament depolymerization →	+0.195	+1.624	<.001	<.001	3	8
BONE	Peptidyl-lysine oxidation →	+1.410	+1.427	<.001	<.001	3	8
BONE	Negative regulation of small GTPase mediated signal transduction →	+0.075	+1.362	<.001	<.001	3	8
SOFT_TISSUE	Positive regulation of cytoskeleton organization →	+0.063	+1.634	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,302 associations by consensus.

Positive regulation of establishment of T cell polarity by AFF3 expression — BONE

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