AFF3

Across TCGA cell cohorts, AFF3 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFF3-associated genes across cancer lineages are GOLGA6L6, C20orf85, and OR1L4. Each is linked with AFF3 in more than 3 cancer types. Because this analysis shows association rather than direction, both AFF3-to-partner and partner-to-AFF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6L6 grouped by AFF3-low versus AFF3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF3→partner) and Y-score (partner→AFF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GOLGA6L6 →	+0.009	+4.369	<.001	.008	3	4
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	2
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	2
BLOOD_Leukemia	SMIM31 →	+0.021	+4.691	<.001	<.001	3	2
LUNG_NSCLC_LUAD	MAP3K19 →	+0.043	+3.929	<.001	<.001	3	2
LARGE_INTESTINE	ATP5F1A →	+0.714	+2.541	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

GOLGA6L6 by AFF3 expression — SOFT_TISSUE

Explore this box plot interactively →