AFF2

Across TCGA patient cohorts, AFF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,703 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AFF2-associated proteins across cancer lineages are EPB41L2, ABCC4_S404, and EPB41L2_S715. Each is linked with AFF2 in more than 4 cancer types. Because this analysis shows association rather than direction, both AFF2-to-partner and partner-to-AFF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFF2 versus EPB41L2 in BRCA, with a Pearson correlation of 0.25.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF2→partner) and Y-score (partner→AFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EPB41L2 →	+0.532	+0.328	<.001	<.001	3	5
LUAD	ABCC4_S404 →	+0.579	+0.512	.001	.003	3	4
UCEC	EPB41L2_S715 →	+0.599	+1.227	<.001	<.001	3	4
GBM	TMEM30A →	+0.325	+0.754	<.001	<.001	3	3
OV	TRERF1_S491 →	-0.861	-1.267	.002	.003	3	3
HNSC	PLIN3 →	-0.329	-0.773	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,703 associations by consensus.

AFF2 vs EPB41L2 — BRCA

Explore this scatter interactively →