AFF2

Across TCGA patient cohorts, AFF2 mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFF2-associated genes across cancer lineages are eIF4G, FoxM1, and GAPDH. Each is linked with AFF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AFF2-to-partner and partner-to-AFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by AFF2-low versus AFF2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF2→partner) and Y-score (partner→AFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4G →	+0.477	+2.000	.024	.030	3	4
STAD	FoxM1 →	+0.527	+3.616	<.001	.001	3	3
COAD	GAPDH →	+0.388	+1.511	.020	.018	3	3
STAD	Ku80 →	+0.327	+3.459	.008	.004	3	3
COAD	PR →	-0.145	-1.493	.041	.028	3	3
HNSC	Collagen-VI →	-0.470	-3.169	.014	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

eIF4G by AFF2 expression — STAD

Explore this box plot interactively →