AFF2

Across TCGA cell cohorts, AFF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,436 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AFF2-associated GO terms across cancer lineages are Nuclear speck organization, Potassium ion transport, and Potassium ion transmembrane transport. Each is linked with AFF2 in more than 11 cancer types. Because this analysis shows association rather than direction, both AFF2-to-partner and partner-to-AFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear speck organization grouped by AFF2-low versus AFF2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF2→partner) and Y-score (partner→AFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Nuclear speck organization →	-0.276	-0.360	.003	.002	3	12
OVARY	Potassium ion transport →	-0.070	-0.234	<.001	.005	3	8
OVARY	Potassium ion transmembrane transport →	-0.050	-0.195	.002	.004	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle phase transition →	+0.054	+0.122	<.001	.005	3	7
LUNG_NSCLC_LUSC	Pre-miRNA processing →	+0.105	+0.793	<.001	.007	3	7
BREAST	Gamma-aminobutyric acid signaling pathway →	-0.165	-0.670	.003	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,436 associations by consensus.

Nuclear speck organization by AFF2 expression — LUNG_NSCLC_LUAD

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