AFF2

Across TCGA cell cohorts, AFF2 mutation is significantly associated with the RNA expression of many other genes, with 2,786 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFF2-associated genes across cancer lineages are POTEF, ZNF155, and POTEM. Each is linked with AFF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFF2-to-partner and partner-to-AFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEF grouped by AFF2-low versus AFF2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFF2→partner) and Y-score (partner→AFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POTEF →	+1.016	+3.376	<.001	.002	3	2
LUNG_NSCLC_LUAD	ZNF155 →	-0.713	-2.475	<.001	.006	3	2
LUNG_NSCLC_LUAD	POTEM →	+0.206	+1.977	.001	.005	3	2
LARGE_INTESTINE	TBL1X →	+0.901	+2.458	.006	<.001	3	2
LARGE_INTESTINE	RPL34 →	+0.546	+3.130	.001	<.001	3	2
LARGE_INTESTINE	LANCL1 →	+0.920	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,786 associations by consensus.

POTEF by AFF2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →