AFAP1L2

Across TCGA patient cohorts, AFAP1L2 mutation is significantly associated with the RNA expression of many other genes, with 2,773 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFAP1L2-associated genes across cancer lineages are CENPH, CDCA2, and PSAT1P4. Each is linked with AFAP1L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFAP1L2-to-partner and partner-to-AFAP1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPH grouped by AFAP1L2-low versus AFAP1L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L2→partner) and Y-score (partner→AFAP1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPH →	+0.603	+2.906	<.001	.001	3	3
UCEC	CDCA2 →	+0.727	+2.922	<.001	<.001	3	3
UCEC	PSAT1P4 →	+0.101	+1.670	.008	.002	3	3
UCEC	KIF11 →	+0.576	+1.557	.008	.009	3	3
UCEC	MBD1 →	+0.405	+2.828	<.001	.001	3	3
BLCA	MIR5007 →	+0.459	+4.147	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,773 associations by consensus.

CENPH by AFAP1L2 expression — UCEC

Explore this box plot interactively →