AFAP1L2

Across TCGA cell cohorts, AFAP1L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,603 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AFAP1L2-associated GO terms across cancer lineages are Rho protein signal transduction, Chaperone-mediated autophagy, and Positive regulation of protein localization to nucleus. Each is linked with AFAP1L2 in more than 9 cancer types. Because this analysis shows association rather than direction, both AFAP1L2-to-partner and partner-to-AFAP1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rho protein signal transduction grouped by AFAP1L2-low versus AFAP1L2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L2→partner) and Y-score (partner→AFAP1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Rho protein signal transduction →	+0.105	+1.845	.001	.001	3	10
PANCREAS	Chaperone-mediated autophagy →	+0.146	+1.813	.002	.001	3	10
STOMACH	Positive regulation of protein localization to nucleus →	+0.097	+2.683	.001	.001	3	9
STOMACH	Negative regulation of protein-containing complex assembly →	+0.078	+2.622	.002	.002	3	9
STOMACH	Positive regulation of DNA-templated transcription, elongation →	+0.080	+2.477	.002	.003	3	9
LIVER	Positive regulation of canonical NF-kappaB signal transduction →	+0.065	+2.606	.002	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,603 associations by consensus.

Rho protein signal transduction by AFAP1L2 expression — OESOPHAGUS

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