AFAP1L2

Across TCGA cell cohorts, AFAP1L2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AFAP1L2-associated genes across cancer lineages are HHLA1, ELOA3DP, and ARGFX. Each is linked with AFAP1L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFAP1L2-to-partner and partner-to-AFAP1L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by AFAP1L2-low versus AFAP1L2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L2→partner) and Y-score (partner→AFAP1L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	2
LARGE_INTESTINE	ELOA3DP →	+0.044	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	ARGFX →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	SCYGR2 →	+0.052	+4.437	<.001	.004	3	1
BLOOD_Leukemia	TNP1 →	+0.134	+4.984	<.001	.002	3	1
BLOOD_Leukemia	DIRAS2 →	+0.099	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

HHLA1 by AFAP1L2 expression — BLOOD_Leukemia

Explore this box plot interactively →