Across TCGA pan-cancer cohorts, AFAP1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AFAP1 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.
The strongest signal is observed in small cell lung cancer (SCLC), where higher AFAP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AFAP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.
SCLC, UCEC, and STAD are the cancer types where AFAP1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.