Across TCGA pan-cancer cohorts, AFAP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AFAP1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher AFAP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AFAP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where AFAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.244	0.478	<.001	44	view →
CCRCC	DFS	Tertile	IV	0.908	0.162	.024	8	view →
LSCC	DFS	Median	All	0.461	0.861	.028	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: AFAP1 tumor-vs-normal RNA expression · all AFAP1 data types