Across TCGA patient cohorts, AFAP1 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFAP1-associated genes across cancer lineages are Cyclin-E2, ERK2, and FoxM1. Each is linked with AFAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AFAP1-to-partner and partner-to-AFAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1→partner) and Y-score (partner→AFAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.207	+3.025	.048	.018	3	4
UCEC	ERK2 →	+0.190	+1.999	<.001	.002	3	3
UCEC	FoxM1 →	+0.157	+1.432	.039	.005	3	3
UCEC	p70-S6K_pT389 →	-0.150	-1.058	.007	.037	3	3
UCEC	4E-BP1 →	+0.288	+1.857	<.001	<.001	3	3
STAD	eEF2 →	+0.430	+3.000	.005	.036	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

AFAP1 survival (RNA) · tumor vs normal (RNA) · all AFAP1 data types