Across TCGA cell cohorts, AFAP1 mutation is significantly associated with the RNA expression of many other genes, with 465 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFAP1-associated genes across cancer lineages are GAL3ST2, CXorf58, and HHLA3. Each is linked with AFAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFAP1-to-partner and partner-to-AFAP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1→partner) and Y-score (partner→AFAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GAL3ST2 →	+1.747	+3.502	<.001	.001	3	2
LARGE_INTESTINE	CXorf58 →	+0.069	+3.234	.002	.005	3	2
LARGE_INTESTINE	HHLA3 →	+0.852	+2.451	.004	.009	3	2
BLOOD_Leukemia	FGF21 →	+0.198	+3.966	<.001	<.001	3	1
BLOOD_Leukemia	POU6F2 →	+0.476	+2.930	<.001	.005	3	1
BLOOD_Leukemia	FOXN1 →	+0.027	+2.681	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 465 associations by consensus.

Exploration

AFAP1 survival (RNA) · tumor vs normal (RNA) · all AFAP1 data types