AEN

Across TCGA patient cohorts, AEN mutation is significantly associated with the RNA expression of many other genes, with 764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AEN-associated genes across cancer lineages are RNU7-138P, RNA5SP68, and RN7SKP146. Each is linked with AEN in more than 1 cancer types. Because this analysis shows association rather than direction, both AEN-to-partner and partner-to-AEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-138P grouped by AEN-low versus AEN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AEN→partner) and Y-score (partner→AEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU7-138P →	+0.402	+5.087	.001	.004	3	2
COAD	RNA5SP68 →	+0.863	+5.145	<.001	.007	3	2
BLCA	RN7SKP146 →	+0.111	+5.177	<.001	.007	3	2
LUAD	CNGA2 →	+0.473	+5.116	<.001	.001	3	1
LUAD	RN7SKP139 →	+0.147	+5.444	<.001	.002	3	1
LUAD	AKR1B1P6 →	+0.091	+4.399	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 764 associations by consensus.

RNU7-138P by AEN expression — LUAD

Explore this box plot interactively →