AEN

Across TCGA patient cohorts, AEN mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AEN-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ACC1. Each is linked with AEN in more than 1 cancer types. Because this analysis shows association rather than direction, both AEN-to-partner and partner-to-AEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by AEN-low versus AEN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AEN→partner) and Y-score (partner→AEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-3.143	.009	.018	3	1
UCEC	EGFR_pY1068 →	-0.303	-3.000	.009	.036	3	1
UCEC	ACC1 →	+0.372	+2.820	.028	.035	3	1
UCEC	Heregulin →	-0.144	-3.169	.012	.019	3	1
UCEC	IRS1 →	-0.211	-3.169	.029	.019	3	1
UCEC	MEK1 →	+0.416	+2.459	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

14-3-3_beta by AEN expression — UCEC

Explore this box plot interactively →