AEN

Across TCGA cell cohorts, AEN mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AEN-associated genes across cancer lineages are C1QTNF7, GYPA, and HNRNPCL4. Each is linked with AEN in more than 1 cancer types. Because this analysis shows association rather than direction, both AEN-to-partner and partner-to-AEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QTNF7 grouped by AEN-low versus AEN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AEN→partner) and Y-score (partner→AEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QTNF7 →	+0.154	+4.108	<.001	.008	3	1
LARGE_INTESTINE	GYPA →	+0.110	+3.793	<.001	.007	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.110	+3.793	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
STOMACH	ASB10 →	+0.016	+5.285	<.001	.003	3	1
STOMACH	OR2T35 →	+0.040	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C1QTNF7 by AEN expression — LARGE_INTESTINE

Explore this box plot interactively →