AEN

Across TCGA cell cohorts, AEN mutation is significantly associated with the mutation status of many other genes, with 959 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AEN-associated genes across cancer lineages are GABRR1, SLC35G1, and TRABD2A. Each is linked with AEN in more than 2 cancer types. Because this analysis shows association rather than direction, both AEN-to-partner and partner-to-AEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRR1 grouped by AEN-low versus AEN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AEN→partner) and Y-score (partner→AEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GABRR1 →	+5.824	+5.824	.002	.002	1	3
SKIN	SLC35G1 →	+5.824	+5.824	.002	.002	1	3
OVARY	TRABD2A →	+5.415	+5.415	.004	.004	1	3
LARGE_INTESTINE	CRTC3 →	+3.744	+5.000	<.001	<.001	1	3
BLOOD_Leukemia	CEP135 →	+3.050	+3.247	.008	.008	1	3
LARGE_INTESTINE	TMEM132A →	+2.159	+3.807	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 959 associations by consensus.

GABRR1 by AEN expression — SKIN

Explore this box plot interactively →