AEBP2

Across TCGA patient cohorts, AEBP2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AEBP2-associated genes across cancer lineages are A-Raf_pS299, S6_pS240_S244, and STAT5a. Each is linked with AEBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AEBP2-to-partner and partner-to-AEBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by AEBP2-low versus AEBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AEBP2→partner) and Y-score (partner→AEBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.173	-3.169	<.001	.019	3	2
UCEC	S6_pS240_S244 →	+0.433	+2.222	.011	.011	3	2
UCEC	STAT5a →	+0.449	+2.906	.008	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.826	+2.604	.001	.005	3	2
UCEC	14-3-3_beta →	-0.167	-3.432	<.001	.005	3	1
UCEC	eEF2 →	+0.372	+1.700	.014	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by AEBP2 expression — UCEC

Explore this box plot interactively →