ADSS2

Across TCGA patient cohorts, ADSS2 mutation is significantly associated with the RNA expression of many other genes, with 2,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADSS2-associated genes across cancer lineages are RNA5SP531, RNU6-839P, and RNA5SP391. Each is linked with ADSS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADSS2-to-partner and partner-to-ADSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP531 grouped by ADSS2-low versus ADSS2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADSS2→partner) and Y-score (partner→ADSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP531 →	+0.263	+4.706	.002	.007	3	3
STAD	RNU6-839P →	+0.706	+5.274	<.001	.006	3	2
STAD	RNA5SP391 →	+0.834	+5.026	<.001	.009	3	2
STAD	RNU6-1119P →	+1.034	+5.366	<.001	.005	3	2
STAD	RNA5SP176 →	+1.262	+5.463	<.001	.005	3	2
STAD	MIR1305 →	+0.651	+5.026	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,105 associations by consensus.

RNA5SP531 by ADSS2 expression — LUSC

Explore this box plot interactively →