ADSS2

Across TCGA cell cohorts, ADSS2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADSS2-associated genes across cancer lineages are ITGAD, ACER1, and OR10W1. Each is linked with ADSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADSS2-to-partner and partner-to-ADSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by ADSS2-low versus ADSS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADSS2→partner) and Y-score (partner→ADSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.077	+3.145	.003	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
BLOOD_Leukemia	C1QL2 →	+0.017	+4.507	<.001	.001	3	1
BLOOD_Leukemia	PTF1A →	+0.301	+4.060	<.001	.003	3	1
BLOOD_Leukemia	KRTAP4-7 →	+0.033	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ITGAD by ADSS2 expression — LARGE_INTESTINE

Explore this box plot interactively →