Across TCGA pan-cancer cohorts, ADSS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ADSS1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ADSS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADSS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where ADSS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.294	0.581	<.001	90	view →
LUAD	OS	Median	II,III,IV	0.353	0.924	<.001	62	view →
UCEC	OS	Median	All	0.826	1.000	<.001	32	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	19	view →
LSCC	DFS	Tertile	All	0.427	1.000	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ADSS1 tumor-vs-normal RNA expression · all ADSS1 data types