Across TCGA pan-cancer cohorts, ADSS1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ADSS1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ADSS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ADSS1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where ADSS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADSS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+1.107	<.001	9	view →
HNSC	All	II,III,IV	−1.164	<.001	7	view →
LUAD	Male	All	+0.562	<.001	7	view →
LSCC	Female	III,IV	+0.640	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ADSS1 RNA expression & survival · all ADSS1 data types