Across TCGA patient cohorts, ADSS1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADSS1-associated genes across cancer lineages are mTOR_pS2448, Notch1, and Bak. Each is linked with ADSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADSS1-to-partner and partner-to-ADSS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADSS1→partner) and Y-score (partner→ADSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.142	-3.308	.018	.009	3	2
UCEC	Notch1 →	+0.218	+4.169	<.001	<.001	3	2
UCEC	Bak →	+0.254	+2.459	.011	.019	3	2
UCEC	c-Met_pY1235 →	+0.069	+1.906	.020	.016	3	2
UCEC	Cyclin-E2 →	+0.178	+2.415	.008	.003	3	2
UCEC	HER3_pY1289 →	+0.089	+2.341	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

ADSS1 survival (RNA) · tumor vs normal (RNA) · all ADSS1 data types