ADSL

Across TCGA patient cohorts, ADSL mutation is significantly associated with the RNA expression of many other genes, with 1,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADSL-associated genes across cancer lineages are RNA5SP414, RPS21P8, and RNA5SP416. Each is linked with ADSL in more than 1 cancer types. Because this analysis shows association rather than direction, both ADSL-to-partner and partner-to-ADSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by ADSL-low versus ADSL-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADSL→partner) and Y-score (partner→ADSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP414 →	+0.143	+7.471	.001	.008	3	2
HNSC	RPS21P8 →	+0.174	+6.468	<.001	.001	3	2
BRCA	RNA5SP416 →	+0.669	+7.471	<.001	.008	3	2
COAD	ATP5MC1P8 →	+0.487	+2.542	<.001	.008	3	2
COAD	RN7SL83P →	+0.242	+4.169	<.001	.001	3	2
COAD	OR5M2P →	+0.038	+5.153	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,615 associations by consensus.

RNA5SP414 by ADSL expression — BRCA

Explore this box plot interactively →