ADSL

Across TCGA patient cohorts, ADSL mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADSL-associated genes across cancer lineages are MSH2, p38-MAPK_pT180_Y182, and PCNA. Each is linked with ADSL in more than 1 cancer types. Because this analysis shows association rather than direction, both ADSL-to-partner and partner-to-ADSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ADSL-low versus ADSL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADSL→partner) and Y-score (partner→ADSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.264	-2.433	.011	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.459	-3.169	.023	.019	3	1
UCEC	PCNA →	+0.245	+3.459	.011	.005	3	1
UCEC	STAT5a →	+0.490	+3.169	.006	.019	3	1
UCEC	ATM →	-0.406	-3.169	.047	.019	3	1
COAD	GSK-3_pS9 →	-0.449	-2.991	.026	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSH2 by ADSL expression — UCEC

Explore this box plot interactively →