Across TCGA patient cohorts, ADRB3 mutation is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRB3-associated genes across cancer lineages are TRAV1-1, POLR3D, and TRAJ37. Each is linked with ADRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRB3-to-partner and partner-to-ADRB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB3→partner) and Y-score (partner→ADRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAV1-1 →	+0.419	+3.237	.003	.009	3	2
UCEC	POLR3D →	+0.725	+3.480	<.001	.002	3	2
UCEC	TRAJ37 →	+0.588	+2.496	.003	.004	3	2
UCEC	TRGJP2 →	+0.693	+2.403	<.001	.008	3	2
UCEC	FAR1P1 →	+0.090	+2.919	.005	<.001	3	2
UCEC	RNU6-1213P →	+0.315	+4.292	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

Exploration

ADRB3 survival (RNA) · tumor vs normal (RNA) · all ADRB3 data types