Across TCGA cell cohorts, ADRB3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ADRB3-associated genes across cancer lineages are MAGEB5, IFNG, and CFHR2. Each is linked with ADRB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRB3-to-partner and partner-to-ADRB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB3→partner) and Y-score (partner→ADRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	IFNG →	+0.220	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
CNS	APOBEC1 →	+0.022	+5.754	<.001	.002	3	1
CNS	IL21 →	+0.025	+4.981	<.001	.008	3	1
CNS	LYZL2 →	+0.021	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

ADRB3 survival (RNA) · tumor vs normal (RNA) · all ADRB3 data types