ADRB2

Across TCGA patient cohorts, ADRB2 mutation is significantly associated with the RNA expression of many other genes, with 2,652 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRB2-associated genes across cancer lineages are NPVF, OR13D1, and PRAMEF10. Each is linked with ADRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRB2-to-partner and partner-to-ADRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by ADRB2-low versus ADRB2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB2→partner) and Y-score (partner→ADRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NPVF →	+0.052	+5.739	<.001	.001	3	2
LUAD	OR13D1 →	+0.543	+4.218	<.001	.009	3	2
LUAD	PRAMEF10 →	+0.041	+5.584	<.001	.002	3	2
LUAD	MIR128-1 →	+1.177	+4.568	<.001	.004	3	2
LUAD	DHFRP6 →	+0.771	+4.481	<.001	.009	3	2
LUAD	RN7SKP58 →	+0.469	+4.554	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,652 associations by consensus.

NPVF by ADRB2 expression — LUAD

Explore this box plot interactively →