ADRB2

Across TCGA patient cohorts, ADRB2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRB2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and INPP4B. Each is linked with ADRB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADRB2-to-partner and partner-to-ADRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADRB2-low versus ADRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB2→partner) and Y-score (partner→ADRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.773	+1.502	<.001	.030	3	3
UCEC	14-3-3_beta →	-0.120	-2.673	.001	.005	3	2
UCEC	INPP4B →	-0.260	-2.807	.028	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.171	-2.115	.005	.017	3	2
UCEC	mTOR_pS2448 →	-0.157	-3.446	.004	.005	3	2
UCEC	p70-S6K →	+0.162	+1.874	.022	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by ADRB2 expression — UCEC

Explore this box plot interactively →