ADRA2B

Across TCGA patient cohorts, ADRA2B mutation is significantly associated with the RNA expression of many other genes, with 2,809 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRA2B-associated genes across cancer lineages are OGFOD2, RGS3, and GPN2. Each is linked with ADRA2B in more than 2 cancer types. Because this analysis shows association rather than direction, both ADRA2B-to-partner and partner-to-ADRA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OGFOD2 grouped by ADRA2B-low versus ADRA2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2B→partner) and Y-score (partner→ADRA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OGFOD2 →	+0.204	+1.836	.003	.001	3	3
UCEC	RGS3 →	+0.337	+1.847	.001	<.001	3	3
UCEC	GPN2 →	+0.283	+2.177	.002	.001	3	3
COAD	ZBTB17 →	+0.505	+3.250	.002	.009	2	3
COAD	MINK1 →	+0.646	+3.210	<.001	.009	3	2
COAD	ATP5F1A →	+0.536	+3.210	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,809 associations by consensus.

OGFOD2 by ADRA2B expression — UCEC

Explore this box plot interactively →