ADRA2B

Across TCGA cell cohorts, ADRA2B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,714 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ADRA2B-associated GO terms across cancer lineages are Proton motive force-driven ATP synthesis, Proton motive force-driven mitochondrial ATP synthesis, and Purine nucleoside triphosphate biosynthetic process. Each is linked with ADRA2B in more than 10 cancer types. Because this analysis shows association rather than direction, both ADRA2B-to-partner and partner-to-ADRA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proton motive force-driven ATP synthesis grouped by ADRA2B-low versus ADRA2B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2B→partner) and Y-score (partner→ADRA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Proton motive force-driven ATP synthesis →	+0.085	+0.331	.001	<.001	3	11
LUNG_SCLC	Proton motive force-driven mitochondrial ATP synthesis →	+0.084	+0.284	.001	.002	3	10
LUNG_SCLC	Purine nucleoside triphosphate biosynthetic process →	+0.092	+0.376	.001	.002	3	9
LUNG_SCLC	Purine ribonucleoside triphosphate biosynthetic process →	+0.092	+0.376	.001	.002	3	9
OVARY	Nucleoside triphosphate biosynthetic process →	+0.104	+0.490	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.042	+0.135	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,714 associations by consensus.

Proton motive force-driven ATP synthesis by ADRA2B expression — LUNG_SCLC

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