ADRA2B

Across TCGA cell cohorts, ADRA2B mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADRA2B-associated genes across cancer lineages are APOL5, LYPD4, and BRDT. Each is linked with ADRA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA2B-to-partner and partner-to-ADRA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by ADRA2B-low versus ADRA2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2B→partner) and Y-score (partner→ADRA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	2
LARGE_INTESTINE	LYPD4 →	+0.047	+2.657	.001	.007	3	1
BLOOD_Leukemia	BRDT →	+0.143	+4.342	<.001	.002	3	1
BLOOD_Leukemia	UNC45B →	+0.108	+4.408	.005	.001	3	1
BLOOD_Leukemia	NKX6-1 →	+0.662	+3.787	<.001	.004	3	1
BLOOD_Leukemia	DCLK3 →	+0.258	+4.091	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

APOL5 by ADRA2B expression — BLOOD_Leukemia

Explore this box plot interactively →