ADRA2A

Across TCGA patient cohorts, ADRA2A mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRA2A-associated genes across cancer lineages are MEK1, MSH2, and p21. Each is linked with ADRA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA2A-to-partner and partner-to-ADRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ADRA2A-low versus ADRA2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2A→partner) and Y-score (partner→ADRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.440	+1.947	<.001	<.001	3	2
COAD	MSH2 →	-0.372	-3.161	<.001	.019	3	2
UCEC	p21 →	+0.170	+1.765	.003	.013	3	2
UCEC	Rad50 →	-0.182	-1.263	.014	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.684	+2.267	<.001	<.001	3	2
UCEC	C-Raf →	+0.156	+2.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by ADRA2A expression — UCEC

Explore this box plot interactively →