ADRA2A

Across TCGA cell cohorts, ADRA2A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,964 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADRA2A-associated GO terms across cancer lineages are Negative regulation of calcium ion-dependent exocytosis, Endosomal transport, and Retrograde transport, endosome to Golgi. Each is linked with ADRA2A in more than 6 cancer types. Because this analysis shows association rather than direction, both ADRA2A-to-partner and partner-to-ADRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion-dependent exocytosis grouped by ADRA2A-low versus ADRA2A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2A→partner) and Y-score (partner→ADRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of calcium ion-dependent exocytosis →	-0.122	-1.225	<.001	.001	3	7
LUNG_SCLC	Endosomal transport →	+0.040	+1.488	.007	.004	3	7
LUNG_SCLC	Retrograde transport, endosome to Golgi →	+0.042	+1.601	.003	.002	3	7
BLOOD_Lymphoma	Astral microtubule organization →	+0.094	+0.012	.003	.005	3	6
CNS	Regulation of macroautophagy →	+0.030	+0.483	<.001	.003	3	5
CNS	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.046	+0.566	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,964 associations by consensus.

Negative regulation of calcium ion-dependent exocytosis by ADRA2A expression — LUNG_SCLC

Explore this box plot interactively →