ADRA2A

Across TCGA cell cohorts, ADRA2A mutation is significantly associated with the RNA expression of many other genes, with 549 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADRA2A-associated genes across cancer lineages are C5orf60, ELOA2, and ELOA3CP. Each is linked with ADRA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA2A-to-partner and partner-to-ADRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf60 grouped by ADRA2A-low versus ADRA2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2A→partner) and Y-score (partner→ADRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C5orf60 →	+0.095	+3.299	<.001	.004	3	2
LARGE_INTESTINE	ELOA2 →	+0.043	+3.647	<.001	.001	3	2
LARGE_INTESTINE	ELOA3CP →	+0.132	+2.450	<.001	.007	3	2
OESOPHAGUS	CRYGA →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	SMIM23 →	+0.023	+4.906	<.001	.006	3	1
BLOOD_Leukemia	IL5 →	+0.197	+3.590	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 549 associations by consensus.

C5orf60 by ADRA2A expression — LARGE_INTESTINE

Explore this box plot interactively →