ADRA2A

Across TCGA cell cohorts, ADRA2A mutation is significantly associated with the mutation status of many other genes, with 5,516 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADRA2A-associated genes across cancer lineages are TRPA1, XYLT2, and CTTNBP2. Each is linked with ADRA2A in more than 4 cancer types. Because this analysis shows association rather than direction, both ADRA2A-to-partner and partner-to-ADRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPA1 grouped by ADRA2A-low versus ADRA2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA2A→partner) and Y-score (partner→ADRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRPA1 →	+3.498	+3.498	<.001	<.001	1	5
BLOOD_Lymphoma	XYLT2 →	+3.969	+3.969	.002	.002	1	5
BLOOD_Leukemia	CTTNBP2 →	+3.275	+3.665	<.001	<.001	1	5
BLOOD_Lymphoma	NLGN2 →	+3.554	+3.731	.003	.003	1	5
BLOOD_Leukemia	TDRD6 →	+2.498	+2.624	.008	.008	1	5
LARGE_INTESTINE	ATRN →	+2.471	+2.584	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,516 associations by consensus.

TRPA1 by ADRA2A expression — BLOOD_Leukemia

Explore this box plot interactively →