ADRA1D

Across TCGA patient cohorts, ADRA1D mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADRA1D-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1173, and Ku80. Each is linked with ADRA1D in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA1D-to-partner and partner-to-ADRA1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ADRA1D-low versus ADRA1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA1D→partner) and Y-score (partner→ADRA1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.143	-3.156	.024	.018	3	2
UCEC	EGFR_pY1173 →	+0.079	+2.999	.020	.035	3	1
UCEC	Ku80 →	+0.228	+2.469	.023	.010	3	1
UCEC	PDCD4 →	-0.548	-1.700	.006	.044	3	1
UCEC	Annexin-1 →	+0.510	+3.019	.022	.019	3	1
UCEC	VHL →	-1.181	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

mTOR_pS2448 by ADRA1D expression — UCEC

Explore this box plot interactively →